What does the mediodorsal thalamus do?

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What does the mediodorsal thalamus do?

Dense amnesia can result from damage to the medial diencephalon in humans and in animals. In humans this damage is diffuse and can include the mediodorsal nuclei of the thalamus. In animal models, lesion studies have confirmed the mediodorsal thalamus (MD) has a role in memory and other cognitive tasks, although the extent of deficits is mixed. Anatomical tracing studies confirm at least three ...

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Inhibition of Mediodorsal Thalamus Disrupts Thalamofrontal Connectivity and Cognition

Cognitive deficits are central to schizophrenia, but the underlying mechanisms still remain unclear. Imaging studies performed in patients point to decreased activity in the mediodorsal thalamus (MD) and reduced functional connectivity between the MD and prefrontal cortex (PFC) as candidate mechanisms. However, a causal link is still missing. We used a pharmacogenetic approach in mice to dimini...

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Mediodorsal thalamus and cognition in non-human primates

Several recent studies in non-human primates have provided new insights into the role of the medial thalamus in different aspects of cognitive function. The mediodorsal nucleus of the thalamus (MD), by virtue of its connectivity with the frontal cortex, has been implicated in an array of cognitive functions. Rather than serving as an engine or relay for the prefrontal cortex, this area seems to...

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ژورنال

عنوان ژورنال: Frontiers in Systems Neuroscience

سال: 2013

ISSN: 1662-5137

DOI: 10.3389/fnsys.2013.00037